CBD 3x more effective for seizures than pharmaceuticals

Posted by Heather Brady on

CBD has been proven 3x more effective than pharmaceuticals for seizures.

One of the most effective treatments for seizures for any animal- human, feline, or canine, has been cannabis. “In 2018, the FDA approved the first cannabis-derived pharmaceutical, Epidiolex. A single-molecule CBD formulation, Epidiolex is approved for the use of refractory seizures in two forms of pediatric epilepsy known as Lennox-Gastaut and Dravet Syndromes.”

Epidiolex is the first cannabis derived pharmaceutical – a two molecule CBD formulation approved for pediatric use. Cannabidiol is of great benefit for seizure prevention and management, this declaration was also represented a positive step forward in the federal government’s acknowledgement of the medicinal value of cannabis.

Epilepsy is one of the most common neurological diseases – this is especially true in undeveloped countries. Complexly, one-third of patients with epilepsy have seizures that are resistant to antiepileptic medications and rely on natural treatments. Criminalization of cannabis has compounded treatment options for the significant portion of subjects whose seizures remain refractory to medication. The off-label use of cannabis sativa plant in treating seizures is known since ancient times. The active ingredients being delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), the latter considered safer and more effective in treating seizures, and with much less adverse psychotropic effects.

So it’s been used since the early days, its FDA approved- but does that really mean anything? At Beyond Wellness we go beyond the status quo, and research the Deep science behind the claims. The top 3 direct proof for CBD seizure mitigation is as follows:

  1. CBD Limits GPR55’s (neuron associated with seizure activity.)
    1. CBD decreases excitation of CA1 pyramidal cell - “We describe for the first time a pathophysiologic alteration of GPR55 receptor function due to epilepsy, and report phytocannabinoid effects upon dysfunctional GPR55 signaling consistent with reported anticonvulsant effects.”
  2. Balances AEA concentrations in cerebrospinal fluid.
    1. “Epileptic patients to have reduced anandamide (AEA) concentrations in their cerebrospinal fluid and/or alterations in their CB1 receptors. AEA is one of the naturally occurring neurotransmitters in the body that regulates the endocannabinoid system (ECS). CB1 receptors, also part of the ECS, are binding sites for AEA and changes in AEA and/or CB1 receptors are presumed to lead to changes in levels of other neurotransmitters that may ultimately lead to seizure activity.”
  3. Cannabinoids work as antioxidants- and have neuroactive and neuroprotective properties.
    1. “CBD has been shown to reduce inflammation, protect against neuronal loss, normalize neurogenesis, and act as an antioxidant. These actions appear to be due to the multimodal mechanism of action of CBD in the brain. … Overall, adjunct CBD has been found to be generally safe and effective for treatment-resistant seizures in children with severe early-onset epilepsy. Whether an add-on CBD is efficacious for the long-term treatment of various epilepsy and seizure types in adults being tested in various clinical trials.”

If you haven’t tried CBD and full spectrum cannabinoids for the treatment of seizures, you’re ignoring the most stringently researched and proved effective treatment, three times more effective than pharmaceuticals. If you want to take a deep dive – see below for more in depth studies. CBD and its entourage cannabinoids are the most successful clinical utility in the treatment of refractory epilepsy, seizures associated with infantile spasms, tuberous sclerosis, and Rett syndrome. Plant medicine is the cure.

 

 

REFERENCES:

 

Investigating the Involvement of GPR55 Signaling in the Antiepileptic Effects of Cannabidiol (P5.244) | Neurology

Synaptic effects of cannabinoids | Neurology

Epilepsy and Cannabis: A Literature Review - PubMed (nih.gov)

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center - PubMed (nih.gov)

Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam - PubMed (nih.gov)

Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders - PubMed (nih.gov)

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